Pinkhas Plotkin was born in 1915 in Bobruisk (Belorussia). His family later moved to Liubonichi, where Pinkhas studied in a Yiddish school. After finishing school, he first attended a rabfak (abbr. for "workers' faculty"; it prepared workers to enter institutions of higher education), and later enrolled in the Literature and Linguistics Faculty of the Minsk Pedagogical Institute, from which he graduated in 1939. While a student at the Institute, Pinia became friends with the Yiddish poet Semion Lelchuk, who would be killed in action at the very beginning of the Soviet-German war. The friends published a joint book of poetry in 1940. Later, Plotkin would refer to his friend in his poems. Pinkhas Plotkin's Yiddish poetry was first published in 1934 in the Minsk newspaper Yunger arbeter [The Young Worker], and then in the Minsk journal Shtern [The Star].
Pinkhas Plotkin was drafted into the Red Army in 1939, together with his fellow students. After the beginning of the Soviet-German War on June 22, 1941, Pinkhas, like most of the male population of the Soviet Union, was mobilized for frontline duty. During the war, he fought on the 1st Baltic and the 3rd Belorussian Fronts. Sergeant Plotkin was wounded twice. He was awarded the Order of the Patriotic War, 2nd Class, and some medals.
After the end of the war in May 1945, Pinia Plotkin returned to his native Bobruisk, where he taught Russian language and literature at schools. Back in the summer of 1938, all the Yiddish-language schools in Belorussia had been closed down, with their teachers transferred to either Russian- or Belorussian-language schools. Plotkin combined his teaching career with work as a member of the literary staff of the local newspaper Sovetskaia Rodina. Soon after the launch of the Yiddish journal Sovetish heymland in 1961 in Moscow, Plotkin became a contributor to it. His works also appeared in the newspaper Birobidzhaner shtern, which was published in the Jewish Autonomous Region, in Warsaw's Folkshtime, and in other periodicals. In 1992, Pinia Plotkin left the former USSR for the United States. His works have since been published in various print media in New York, Moscow, and Jerusalem.