Moishe Goldshtein was born in 1901 in Łosice, near Siedlce, Poland. At the age of 16, he came to Warsaw, where he worked at a knitting factory and made his first attempts in literature. In 1926 he emigrated to Argentine, where he worked as a weaver and published short stories in the Yiddish press. In 1931, Goldshtein joined a group of Argentinian Jews who settled in Birobidzhan, in the Soviet Union. There he lived on the Yikor kolkhoz (collective farm), also known as "The New Socialist Town (Sotsshtetl ) of Yikor" (now Kamyshovka, Jewish Autonomous Region). He cut down trees, cleared land, and tried his hand at farming. In 1932, the kolkhoz council sent him to study in Moscow. There he enrolled in a pedagogical institute. In 1934 he published his novel Birobidzhaner afn Amur ("The Birobidzhanians on the Banks of the Amur River"), and in 1937 – Birobidzhaner dertseylungen ("Birobidzhan Stories").
With the beginning of the Soviet-German was in June 1941, Goldshtein was drafted into the Red Army as a military translator 2nd rank. While serving on the frontlines, he wrote brief articles and short stories for the newspaper Eynikayt. His post as a translator did not mean that he remained out of combat. On occasion Goldshtein took part in military operations. On August 11, 1943, while fighting in the area of Smolensk, western Russia, Senior Lieutenant Goldshtein was mortally wounded. He died in a military hospital.